منابع مشابه
Topo II on the move?
p115 SNAREs a vesicle protein known to tether vesicles during intra-Golgi trafficking also ensures their correct docking, according to new results from Shorter et al. (page 45). This provides the first link between the long-range process of tethering and the short-range process of docking. Vesicle transfer consists of four successive reactions: vesicle formation, tethering, docking, and fusion....
متن کامل2-[4-(7-Chloro-2-quinoxalinyloxyphenoxy]-propionic Acid (XK469), an Inhibitor of Topoisomerase (Topo) II , Up-Regulates Topo II and Enhances Topo II -mediated Cytotoxicity
Topoisomerase (Topo) II has proven to be an adequate anticancer target for tumors expressing this enzyme. In this study, we elucidated the effect of 2-[4(7-chloro-2-quinoxalinyloxyphenoxy]-propionic acid (XK469; a new Topo II inhibitor) in the modulation of Topo II levels and sensitivity to Topo II poisons. We demonstrate by Western blot analysis that indolent Bcell tumors express undetectable ...
متن کاملConsistent Rationalization of Topo II Actions
The mathematical basis of the hypothesis that type-2 topoisomerases (topo II) recognize and act at specific DNA juxtapositions was investigated by coarse-grained lattice and continuum wormlike chain models, showing that selective segment passages at hooked juxtapositions can result in dramatic reductions in catenane and knot populations. The lattice modeling approach has recently been extended ...
متن کاملA myosin for RNA Pol II
A myosin for RNA Pol II T ranscription gets a boost from myosin VI, according to fi ndings from Sarah Vreugde (DIBIT Scientifi c Institute, Milano, Italy) and colleagues. The motor might drag genes into transcription neighborhoods. While trying to understand the function of myosin VI, Vreugde noticed that its localization pattern looked much like that of RNA polymerase II. The authors then show...
متن کاملA new player in Pol II pausing.
Transcriptional control plays a primary role in gene expression and can be exerted at multiple levels of the transcription process, such as RNA polymerase recruitment and promoter-proximal pausing. A recent report published in The EMBO Journal (Li and Gilmour, 2013) provides new insights into the regulation of a large class of paused genes through the identification of a novel transcription fac...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2001
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20011003-01